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Contributions To Neurology And Neuroscience, And Awards Received.
1) Characterization of the fine structure and pathology of human
unmyelinated (pain and sympathetic) nerve fibers.
Work done with W. Mair, Institute of Neurology, Queen Square, London. Thesis
and PH.D. degree, London 1970.
2) Discovery of the primary microscopic injury of myelinated nerve
fibers underlying block of electrical impulse conduction, caused by acute
nerve compression.
Work done with Fowler and Gilliatt, Institute of Neurology, Queen Square,
London. Published in Nature, 233:265-266 (1971), and Journal of
Anatomy,113:433-455 (1972).
3) Discovery of the primary microscopic injury of myelinated nerve
fibers, underlying slowing of electrical impulses, caused by chronic
entrapment (carpal tunnel in animals and humans).
Work in collaboration with L. Marotte, D. Neary and Gilliatt, Institute of
Neurology, Queen Square, London (1973-1975). Publications in Journal of
Neurological Sciences (1973) and 24:283-298 (1975)
See also Carpal Tunnel Syndrome, Book by Rosenbaum and Ochoa (1992), Butterworths.
4) First direct documentation (microneurography) of abnormal
electrical discharges in identified sensory nerve fibers during experimental
provocation of paresthesias (pins and needles) in human volunteers.
Work in collaboration with Erik Torebjörk, Dartmouth Medical School and
Academic Hospital, Uppsala, Sweden. Published in Brain, 103:845-853 (1980).
5) Contribution to understanding the biological laws that govern
conscious decoding by the brain of quality, magnitude and localization of
sensations evoked by activation of identified human sensory receptors from
the skin.
Work in collaboration with E. Torebjörk and W. Schady at Dartmouth
Medical School, and Academic Hospital, Uppsala, Sweden (1981-1989). Published
in J. Physiol., 242:633-654 (1983),45:583-599 (1989); Brain, 106:745-760
(1983).
Received annual Prize from Swedish Medical Society 1981.
Awarded Doctor of Science Degree, University of London, 1983.
6) Characterization of the primary nervous apparatus that signals
pain from human muscle.
Work in collaboration with Paolo Marchettini (Milano) and Don Simone at Good
Samaritan Hospital, Portland, Oregon.
Publication in Journal of Neurophysiology 72:883-889 (1994) and Brain
Research, 760:109-116 (1986).
7) Description of cross modality threshold modulation property of
human unmyelinated pain fibers, and prediction of disruption of a heat
sensitive molecular transducer in the excitable membrane of pain nerve fibers
(caused by capsaicin).
Work in collaboration with W. J. Culp and R. Dotson at Good Samaritan
Hospital, Portland,
Publication in Brain, 112:1317-1331 (1989).
8) First direct documentation (microneurography) of chronic
irritation of pain nerve fibers in patients with a particular form of
neuropathic pain.
Work done with Martha Cline and Erik Torebjörk, University of Wisconsin,
Madison, USA. Published in Brain, 112:621-647 (1989).
9) Description of the ABC Syndrome of Pain due to chronic
sensitization of C nociceptor pain fibers.
Published in several books 1986-1999.
10) Description of the Triple Cold syndrome of chronic neuropathic pain,
cold hypersensitivity and cold skin, and its experimental correlate through
selective block of cold sensation.
Work in collaboration with David Yarnitsky (Haifa, Israel).
Publication in the journal Brain, 117:185-197 (1994).
11) Unmasking the placebo nature of symptom relief induced by
"diagnostic sympathetic blocks".
Work in collaboration with Renato Verdugo and Mario Campero, at Good
Samaritan Hospital, Portland, Oregon.
Published in the journal Neurology,44:1003-1010, and 44:1010-1014 (1994).
12) Characterization of the false neurological clinical profile of
painful pseudoneuropathy and its essential differences with structurally
based painful nerve disease.
Work in collaboration with R. Verdugo, M. Campero, and Marco Lacerenza,
Portland, Oregon.
Publications in Neurologic Clinics, 13:351-363 (1995); Journal of
Contemporary Neurology, 2:1-21 (1997), and Editorials in Muscle and Nerve,
16:997-1008 (1993), and Mayo Clinic Proceedings 70:1124-1126 (1995).
13) Alerting about the iatrogenic harm that patients with false
neuropathy receive when they are treated invasively for presumed dysfunction
related to the sympathetic system or to presumed secondary spinal cord
repercussions.
Publications in Chapter "Neuropathic Pain", in Current Therapy in
Neurology, Eds. Johnson and Griffin, Mosby (1996) and Syllabus for
American Academy of Neurology, 1998, and 2000.
14) Documentation (microneurography) of abnormal spontaneous and
stimulus evoked electrical nerve fiber discharges in patients with structurally
based neuropathy.
Work done in collaboration with M. Campero, P. Marchettini and J. Serra.
Publications in Muscle and Nerve,21:1661-1667 (1998).
See also: Book "Abnormal Nerves and Muscles as Impulses Generators, Culp
and Ochoa, 1982, Oxford University Press.
Chapter on Microneurography as a clinical tool, in Book on Electrodiagnosis,
Ed Michael Aminoff, Churchill-Livingstone (1999).
15) BioPhysical Characterization of the unmyelinated nervous
apparatus that signals low temperature from the skin, to evoke cold sensation
in humans. Coauthored with Campero, Serra and Bostock (manuscript in
preparation).
16) Biophysical characterization of subtypes of unmyelinated
sensory and sympathetic nerve fibers of various functional affiliations in
human nerves.
Work in collaboration with Bostock, Campero and Serra.
Publications in Journal of physiology 1999 (and others in preparation).
Competitive Research Grant Awards From The NIH
(National Institutes of Health)
Grant
Number PI
Name Project
Title
1R01NS018315-01 OCHOA,
JOSE SENSATION FROM
ACTIVATION OF SINGLE SENSORY UNITS
7R01NS020703-01 OCHOA,
JOSE SENSATION
FROM ACTIVATION OF SINGLE SENSORY UNITS IN MAN
5R01NS020703-02 OCHOA,
JOSE SENSATION FROM
ACTIVATION OF SINGLE SENSORY UNITS IN MAN
2R01NS020703-03 OCHOA,
JOSE SENSATION
FROM ACTIVATION OF SINGLE SENSORY UNITS IN MAN
7R01NS024740-01 OCHOA,
JOSE SENSATION FROM
ACTIVATION OF SINGLE SENSORY UNITS IN MAN
5R01NS024740-02 OCHOA,
JOSE SENSATION
FROM ACTIVATION OF SINGLE SENSORY UNITS IN MAN
5R01NS024740-03 OCHOA,
JOSE SENSATION
FROM ACTIVATION OF SINGLE SENSORY UNITS IN MAN
5R01NS024740-04 OCHOA,
JOSE SENSATION
FROM ACTIVATION OF SINGLE SENSORY UNITS IN MAN
1R01NS024766-01 OCHOA,
JOSE PAIN
AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
5R01NS024766-02 OCHOA,
JOSE PAIN
AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
5R01NS024766-03 OCHOA,
JOSE PAIN
AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
5R01NS024766-04 OCHOA,
JOSE PAIN
AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
5R01NS024766-05 OCHOA,
JOSE PAIN
AND HYPERALGESIA--MICRONEUROGRAPHY IN PATIENTS
1R01NS028747-01 OCHOA,
JOSE PAINFUL SMALL
CALIBER FIBER NEUROPATHY IN AGING HUMANS
5R01NS028747-02 OCHOA,
JOSE PAINFUL
SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
5R01NS028747-03 OCHOA,
JOSE PAINFUL
SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
5R01NS028747-04 OCHOA,
JOSE PAINFUL
SMALL CALIBER FIBER NEUROPATHY IN AGING HUMANS
5R01NS028747-05 OCHOA,
JOSE PAINFUL
SMALL CALIBER FIBER NEUROPATHY IN AGING
1R01NS033679-01A1 OCHOA, JOSE PAIN
AND PARESTHESIAS IN DIABETIC NEUROPATHY
5R01NS033679-02 OCHOA,
JOSE PAIN
AND PARESTHESIAS IN DIABETIC NEUROPATHY
5R01NS033679-03 OCHOA,
JOSE PAIN
AND PARESTHESIAS IN DIABETIC NEUROPATHY
1R01NS039761-01 OCHOA,
JOSE NEW
APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
5R01NS039761-02 OCHOA,
JOSE NEW
APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
5R01NS039761-03 OCHOA,
JOSE NEW
APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
5R01NS039761-04 OCHOA,
JOSE NEW
APPROACHES TO C NOCICEPTORS IN DIABETIC NEUROPATHY
1R01NS048932-01A2 OCHOA, JOSE PRIMARY
C NOCICEPTORS AND C SYMPATHETICS IN CRPS
5R01NS048932-02 OCHOA,
JOSE PRIMARY
C NOCICEPTORS AND C SYMPATHETICS IN CRPS
5R01NS048932-03 OCHOA,
JOSE PRIMARY
C NOCICEPTORS AND C SYMPATHETICS IN CRPS
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