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Contributions To Neurology And Neuroscience, And Awards Received.
1) Characterization of the fine structure and pathology of human unmyelinated (pain and sympathetic) nerve fibers.
Work done with W. Mair, Institute of Neurology, Queen Square, London. Thesis and PH.D. degree, London 1970.
2) Discovery of the primary microscopic injury of myelinated nerve fibers underlying block of electrical impulse conduction, caused by acute nerve compression.
Work done with Fowler and Gilliatt, Institute of Neurology, Queen Square, London. Published in Nature, 233:265-266 (1971), and Journal of Anatomy,113:433-455 (1972).
3) Discovery of the primary microscopic injury of myelinated nerve fibers, underlying slowing of electrical impulses, caused by chronic entrapment (carpal tunnel in animals and humans).
Work in collaboration with L. Marotte, D. Neary and Gilliatt, Institute of Neurology, Queen Square, London (1973-1975). Publications in Journal of Neurological Sciences (1973) and 24:283-298 (1975)
See also Carpal Tunnel Syndrome, Book by Rosenbaum and Ochoa (1992), Butterworths.
4) First direct documentation (microneurography) of abnormal electrical discharges in identified sensory nerve fibers during experimental provocation of paresthesias (pins and needles) in human volunteers.
Work in collaboration with Erik Torebjörk, Dartmouth Medical School and Academic Hospital, Uppsala, Sweden. Published in Brain, 103:845-853 (1980).
5) Contribution to understanding the biological laws that govern conscious decoding by the brain of quality, magnitude and localization of sensations evoked by activation of identified human sensory receptors from the skin.
Work in collaboration with E. Torebjörk and W. Schady at Dartmouth Medical School, and Academic Hospital, Uppsala, Sweden (1981-1989). Published in J. Physiol., 242:633-654 (1983),45:583-599 (1989); Brain, 106:745-760 (1983).
Received annual Prize from Swedish Medical Society 1981.
Awarded Doctor of Science Degree, University of London, 1983.
6) Characterization of the primary nervous apparatus that signals pain from human muscle.
Work in collaboration with Paolo Marchettini (Milano) and Don Simone at Good Samaritan Hospital, Portland, Oregon.
Publication in Journal of Neurophysiology 72:883-889 (1994) and Brain Research, 760:109-116 (1986).
7) Description of cross modality threshold modulation property of human unmyelinated pain fibers, and prediction of disruption of a heat sensitive molecular transducer in the excitable membrane of pain nerve fibers (caused by capsaicin).
Work in collaboration with W. J. Culp and R. Dotson at Good Samaritan Hospital, Portland,
Publication in Brain, 112:1317-1331 (1989).
8) First direct documentation (microneurography) of chronic irritation of pain nerve fibers in patients with a particular form of neuropathic pain.
Work done with Martha Cline and Erik Torebjörk, University of Wisconsin, Madison, USA. Published in Brain, 112:621-647 (1989).
9) Description of the ABC Syndrome of Pain due to chronic sensitization of C nociceptor pain fibers.
Published in several books 1986-1999.
10) Description of the Triple Cold syndrome of chronic neuropathic pain, cold hypersensitivity and cold skin, and its experimental correlate through selective block of cold sensation.
Work in collaboration with David Yarnitsky (Haifa, Israel).
Publication in the journal Brain, 117:185-197 (1994).
11) Unmasking the placebo nature of symptom relief induced by "diagnostic sympathetic blocks".
Work in collaboration with Renato Verdugo and Mario Campero, at Good Samaritan Hospital, Portland, Oregon.
Published in the journal Neurology,44:1003-1010, and 44:1010-1014 (1994).
12) Characterization of the false neurological clinical profile of painful pseudoneuropathy and its essential differences with structurally based painful nerve disease.
Work in collaboration with R. Verdugo, M. Campero, and Marco Lacerenza, Portland, Oregon.
Publications in Neurologic Clinics, 13:351-363 (1995); Journal of Contemporary Neurology, 2:1-21 (1997), and Editorials in Muscle and Nerve, 16:997-1008 (1993), and Mayo Clinic Proceedings 70:1124-1126 (1995).
13) Alerting about the iatrogenic harm that patients with false neuropathy receive when they are treated invasively for presumed dysfunction related to the sympathetic system or to presumed secondary spinal cord repercussions.
Publications in Chapter "Neuropathic Pain", in Current Therapy in Neurology, Eds. Johnson and Griffin, Mosby (1996) and Syllabus for American Academy of Neurology, 1998, and 2000.
14) Documentation (microneurography) of abnormal spontaneous and stimulus evoked electrical nerve fiber discharges in patients with structurally based neuropathy.
Work done in collaboration with M. Campero, P. Marchettini and J. Serra.
Publications in Muscle and Nerve,21:1661-1667 (1998).
See also: Book "Abnormal Nerves and Muscles as Impulses Generators, Culp and Ochoa, 1982, Oxford University Press.
Chapter on Microneurography as a clinical tool, in Book on Electrodiagnosis, Ed Michael Aminoff, Churchill-Livingstone (1999).
15) BioPhysical Characterization of the unmyelinated nervous apparatus that signals low temperature from the skin, to evoke cold sensation in humans. Coauthored with Campero, Serra and Bostock (manuscript in preparation).
16) Biophysical characterization of subtypes of unmyelinated sensory and sympathetic nerve fibers of various functional affiliations in human nerves.
Work in collaboration with Bostock, Campero and Serra.
Publications in Journal of physiology 1999 (and others in preparation).